Paul L. Leong, M.D. CV

Honors/Awards:

Residency:

• American Head and Neck Society: Resident Research Award, May 14, 2001.
• First Prize, resident research competition. George C. and Robert A. Schein Memorial Resident Research Forum, June 5, 2001.
• Leadership Development Program, American Academy of Otolaryngology – Head and Neck Surgery. (AAO-HNS), 2001.
• AAO-HNS Board of Governors, Big on Goals Award, 2002 and 2003.
• Resident Member, Society of University Otolaryngologists, 2003.
• Selected “Research Star” by AAO-HNS office of research, 2004.
• Richard Holt Leadership Award (AAO-HNS), 2004.

Medical School:

• Howard Hughes Medical Institute Pre-doctoral Fellowship, 1997.
• Farr Scholar for outstanding clinical performance, 1998.
• American Head and Neck Society - Young Investigator Award, 1998.
• American Cancer Society Award - best cancer research by Yale Medical Student. 1999.

Associations:

• American Academy of Otolaryngology – Head and Neck Surgery. 2000-present.
• American Academy of Facial Plastic and Reconstructive Surgery. 2001-present.

Research Experience:

• MD Anderson Cancer Center Undergraduate Research Program. Mentor – Steven Tomasovic, Ph.D. Department of Cell Biology. MD Anderson Cancer Center. Studied synergy of tumor necrosis factor and hyperthermia in blocking angiogenesis in a murine model, Summer 1990.
• NCI Medical Student Research Fellowship. Mentor – Joan Steitz, Ph.D. Department of Molecular Biophysics and Biochemistry. Yale Medical School. Studied DNA-protein binding in context of mRNA processing, Summer 1995.
• Howard Hughes Medical Institute Pre-doctoral Fellowship. Mentor – David Sidransky, MD. Johns Hopkins School of Medicine. Studied clonality and early detection in squamous cell carcinoma, 1997-1998.
• T32 NCI Post-doctoral Fellowship. Mentor – Jennifer Rubin Grandis, MD. Department of Otolaryngology. University of Pittsburgh. Studying cell signaling in squamous cell carcinoma. 2000-2002.
• Clinical Research Training Program. Mentor – Joesph Conigliaro, MD. University of Pittsburgh. Projects addressing racial and regional variation in the treatment of obstructive sleep apnea. 2003-present.
• Functional Rhinoplasty: A Multicenter Prospective Outcomes Study. Mentor – Grant Gillman, MD. University of Pittsburgh. Studying outcomes of functional rhinoplasty on quality of life and nasal airway. 2004-present.
• T32 NIDCD Post-doctoral Fellowship. Mentors – Nancy Day, PhD; Jack Cornelius, MD; Kevin Kramer, MD. University of Pittsburgh. Studying relationship of alcohol consumption and facial trauma, 2005-2006.

Other Experience:

• Management Consultant. American Practice Management/Computer Sciences Corporation (APM/CSC). Helped develop and implement strategies for academic and non-academic health centers to adjust to changes in the health care marketplace. 1994-1995.

Peer-Reviewed Publications:

• Leong PL, Rezai B, Koch WM, Reed A, Eisele D, Lee DJ, Sidransky D, Jen J, Westra WH. Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. J Natl Cancer Ins 90:972-7, 1998.
• Califano J, Leong PL, Koch WM, Eisenberger CF, Sidransky D, Westra WH. Second esophageal tumors in patients with head and neck squamous cell carcinoma: an assessment of clonal relationships. Clin Cancer Res 5:1862-7, 1999.
• Leong PL, Kauffman CL, Moresi JM, Wu L, Jeronimo C, Sidransky DM, Miller SJ. Basal cell carcinoma-like epidermal changes overlying dermatofibromas often reveal loss of heterozygosity in the PTCH gene. J Invest Dermatol 113:279-80, 1999.
• Michael F. Spafford, Wayne M. Koch, Andre L. Reed, Joseph A. Califano, Li H. Xu, Claus F. Eisenberger, Linwah Yip, Paul L. Leong, Li Wu, Shixi X. Liu, Carmen Jeronimo, William H. Westra, and David Sidransky. Detection of Head and Neck Squamous Cell Carcinoma among Exfoliated Oral Mucosal Cells by Microsatellite Analysis. Clin. Cancer Research 7:607-612, 2001.
• Leong PL, Sichuan Xi, Drenning SD, Dyer KF, Wentzel MA, Lerner EC, Smithgall TE, Grandis JR. Differential function of Stat5 isoforms in head and neck cancer growth control. Oncogene 2002 Apr 25;21(18):2846-53.
• Leong PL, Andrews G, Johnson D, Dyer K, Sichuan X, Mai J, Robbins P, Gadiparthi S, Burke N, Watkins S, Grandis J. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proceedings of the National Academy of Sciences 2003 Apr 1; 100(7):4138-4143.

Book Chapters:

• Wang TD, Leong PL. “Treatment of the Widen Nasal Vault.” Comprehensive Facial Plastic Surgery. Submitted.
• Cook TA, Leong PL. “Incision and Excisions.” Comprehensive Facial Plastic Surgery. In preparation.
• Leong PL, Downs BW, Wang TA. “The Male Facelift – Biology and Histology.” North American Clinics of Facial Plastic Surgery. In preparation.

Presentations:

• Leong, PL, Rezai B, Koch W, Reed A, Eisele D, Lee DJ, Sidransky D, Jen J, and Westra W. “Clonal Relationship of Synchronous and Metachronous Tumors of the Head and Neck and Lung: A Genetic Approach for Distinguishing Independent Primary Tumors and Distant Metastases.” AAO-HNS Annual Meeting, San Antonio, TX, 1998. Oral presentation.
• Leong PL, Califano J, Koch W, Lee DJ, Sidransky D and Westra W. Determining Clonal Relationship of “Primary Tumors of the Head and Neck and Second Tumors in the Esophagus.” Abstract Book of Fifth Annual Workshop on Head and Neck Cancer Research, McLean, VA, 1998. Oral presentation. Awarded medical student research prize.

Instruction Courses:

• Wang TD, Leong PL. “Cleft Lip and Palate for Residents”. AAO-HNS Annual Meeting, Washington DC, 2007.